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Welcome to Holiday Inn Express & Suites Mobile – I-65. Tucked just off I-65, our Gulf Coast getaway is a relaxed, smoke-free hotel in Mobile that puts you minutes from Mobile Regional Airport and the lively energy of the University of South Alabama Campus. Spend the day wandering the inspiring galleries at Mobile Museum of Art, breathing in the blooms at Mobile Botanical Gardens, or cheering on the Jaguars at a campus event. Whatever your pace, exploring the Port City is easy from here. Back at our Mobile hotel, settle in and let the little things make your day. Take a refreshing dip in the outdoor pool, fuel up with a complimentary hot breakfast, or get down to business in our dedicated meeting space. We have also stocked the essentials our guests love, including a 24-hour fitness center, free Wi-Fi, and free parking, so you can stay productive, well-rested, and right on schedule. Whether you are visiting for business, family time, or a Gulf Coast adventure, we are ready to make your stay a breeze. Friendly service, smart amenities, and a prime I-65 location come together to deliver the easygoing welcome the Holiday Inn Express & Suites brand is known for. Book your stay today and discover just how comfortable Mobile can feel.